[On 26 male volunteers aged 18 to 70]

Daily application for 2 months.

[On 15 male volunteers with androgenetic alopecia divided into 2 groups]

Daily application (20 drops, in the evening) for 4 months: lotion with 5% Capixyl™ vs placebo.

[On 61 volunteers aged 18 to 60 with alopecia (A/T ratio <4) divided into 2 groups: 30 placebo volunteers / 31 Baicapil™ volunteers]

One application per day to the scalp for 6 months: lotion with Baicapil™ at 3% vs. placebo.

Comparative study:Caffeine 0.2% vs Minoxidil 5%

Conclusion :A 0.2% caffeine lotion is as effective as 5% minoxidil.

[Multicenter randomized clinical trial. 210 men with androgenetic alopecia. Duration: 6 months. Endpoint: Change in the % of hair in the anagen phase.]

Source :KLENK A. & al. An open-label randomized multicenter study assessing the noninferiority of a caffeine-based topical liquid 0.2% versus minoxidil 5% solution in male androgenetic alopecia. Skin Pharmacology and Physiology (2018).

[On 33 male volunteers aged 29 to 70 divided into 2 groups: 16 men placebo group / 17 men EMortal Pep™ group]

One application per day to the scalp for 3 months: lotion with 3% EMortal Pep™ vs. placebo.

[On 60 women aged 18 to 65 with androgenetic alopecia of Ludwig type I to III divided into 2 groups: 20 women placebo / 40 women]

One application per day to the scalp for 6 months: lotion with Niacinamide derivatives vs. placebo.

[Protocol]pilot, randomized, double-blind, placebo-controlled clinical trial.

[ Assessment ]standardized photographic analysis (35 mm formats) to measure hair density.

Sources:JACOBSON MK & al. A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia. Journal of Cosmetic Dermatology (2005) — Draelos ZD (2006). “The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer”. Journal of Cosmetic and Laser Therapy—Gehring, W. (2004). “Niacinamide for skin care management”. Journal of Cosmetic Dermatology.